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Alzheimer’s Disease Data Initiative

Introduction

Datasets(112)

Global Neurodegeneration Proteomics Consortium (GNPC) - Harmonized Dataset V1

Dataset population size: 31,083

OmicsDataType

Brain & Body Donation Program

Dataset population size: 1,077

Health and disease, OmicsDataType

APOE in the Predisposition to, Protection from, and Prevention of Alzheimer's Disease

Dataset population size: 315

Health and disease, OmicsDataType

Indiana Alzheimer's Disease Research Center - Proteomics Minimal Dataset

Dataset population size: 549

Health and disease, OmicsDataType

ALLFTD: ARTFL-LEFFTDS Longitudinal FrontoTemporal Dementia Study

Dataset population size: 802

Health and disease, OmicsDataType

University of Kansas Alzheimer's Disease Research Center - GNPC

Dataset population size: 545

Health and disease, OmicsDataType

BBRC Alfa Plus cohort for GNPC

Dataset population size: 443

Health and disease, OmicsDataType

Dementia Research Group 10/66 - Prevalence Database

Dataset population size: 14,896

Health and disease

BLSA Permissioned Data

Dataset population size: 3,472

Health and disease

The GERAS II Study

Dataset population size: 578

Health and disease

The GERAS Study - EU

Dataset population size: 1,497

Health and disease

The GERAS Study - US

Dataset population size: 1,198

Health and disease

GERAS Cohorts: Harmonized

Dataset population size: 4,328

Health and disease

Alzheimer's Disease and Healthy Aging Data

Dataset population size: 250,937

Health and disease

Blood based 12-miRNA signature of Alzheimer patients - GSE46579

Dataset population size: 70

OmicsDataType

EEG recordings from: Alzheimer's disease, Frontotemporal dementia and Healthy subjects

Dataset population size: 88

Health and disease

Harmonized 1066 MexCog Dataset

Dataset population size: 16,115

Health and disease

Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis - GSE90828

Dataset population size: 23

Health and disease

BCG-PANDA

Dataset population size: 49

Health and disease

BLSA Open Data

Dataset population size: 954

Health and disease

Detection of Alzheimer’s Disease at Mild Cognitive Impairment and Disease Progression Using Autoantibodies as Blood-based Biomarkers - GSE74763

Dataset population size: 100

OmicsDataType

Honolulu-Asia Aging Study

Dataset population size: 3,734

Health and disease

RNAseq in Alzheimer's Disease patients - GSE53697

Dataset population size: 17

OmicsDataType

Dementia Research Group - Incidence Database

Dataset population size: 14,896

Health and disease

Dementia Research Group 10/66 - Life2Years database

Dataset population size: 6,917

Health and disease

The GERAS Study - Japan

Dataset population size: 553

Health and disease

Bio-Hermes

Dataset population size: 1,000

Health and disease, OmicsDataType

Banner Alzheimer's Prevention Initiative - Gen2(CNP520)

Dataset population size: 1,145

Health and disease

Neuropathological quantifications, transcriptome, and in situ proteomics profile datasets for neuronal basis of circadian rhythm dysfunction in tauopa

Dataset population size: 10

OmicsDataType

Banner Alzheimer's Prevention Initiative - Gen1(CAPI015)

Dataset population size: 480

Health and disease

RNA-sequencing of cells derived from dermis and postmortem dura mater from the same subject

Dataset population size: 1

OmicsDataType

Human iPSC Astrocytes and iMGL Transcripts

Dataset population size: 1

OmicsDataType

Single cell RNA-seq data derived from early-onset AD cases and controls

Dataset population size: 16

OmicsDataType

Neurite and whole cell transcriptomics on iNeurons

Dataset population size: 1

OmicsDataType

A reference induced pluripotent stem cell line for large-scale collaborative studies

Dataset population size: 8

OmicsDataType

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

Dataset population size: 15

OmicsDataType

Emory Goizueta Alzheimer’s Disease Research Center – GNPC

Dataset population size: 493

OmicsDataType

North African Dementia Registry (NADR)-Egypt cohort

Dataset population size: 1,500

Health and disease

BORCS6 KD transcriptomics on iNeurons

Dataset population size: 1

OmicsDataType

Plasma biomarkers and cognitive measures in Chinese Americans with Alzheimer’s disease and mild cognitive impairment

Dataset population size: 34

Health and disease

BIOCARD Study

Dataset population size: 477

Health and disease

Mayo Clinic Study of Aging Clinical + PET Data

Dataset population size: 533

Health and disease

DIAN-OB clinical data sharing

Dataset population size: 717

Health and disease, ImagingTypes, OmicsDataType

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s d

Dataset population size: 1

OmicsDataType

EPND Complement Biomarker Study Milliplex

Dataset population size: 325

Health and disease

EPND Complement Biomarker Study Olink 3072

Dataset population size: 328

OmicsDataType

EPND Complement Biomarker Study SVAR Complement Assays

Dataset population size: 341

Health and disease

EPND Complement Biomarker Study Somascan 7k

Dataset population size: 325

OmicsDataType

Brain Cell Type-Specific Enhancer-Promoter Interactome Maps and Disease

Dataset population size: 6

OmicsDataType

Genome-wide H3K27ac profiles in post-mortem entorhinal cortex samples from Alzheimer's disease cases and controls (GSE102538)

Dataset population size: 1

OmicsDataType

MYHAT including Seniors Project

Dataset population size: 2,872

Health and disease

The DAC Early Detection Program - Indiana University New0

Health and disease

ADDIA Alzheimer’s Disease Diagnostics Clinical Study

Dataset population size: 821

Health and disease

EPND ATN study

Dataset population size: 350

Health and disease

CABI database

Dataset population size: 300

Health and disease

Longitudinal Aging Study in India Diagnostic Assessment of Dementia (LASI-DAD)

Dataset population size: 6,168

Health and disease

Psychiatric Ratings using Intermediate Stratified Markers 2 (PRISM2)

Dataset population size: 182

Health and disease, ImagingTypes

Amsterdam Dementia Cohort - Microbiome dataset

Dataset population size: 174

Health and disease

The Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) Study

Dataset population size: 1,984

Health and disease, OmicsDataType

The Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) study

Dataset population size: 288

Health and disease, OmicsDataType

OMICS-AD: Swiss multi-omics in Alzheimer's disease study - clinical data

Dataset population size: 450

Health and disease, OmicsDataType

Answer ALS

Dataset population size: 1,269

Health and disease, OmicsDataType

AMYPAD PNHS (Harmonised and Derived) v202306

Dataset population size: 3,368

Health and disease

Five CSF Proteomic Subtypes in AD (Proteomics)

Dataset population size: 606

OmicsDataType

Heart Failure Synthetic0

Health and disease

Five CSF Proteomic Subtypes in AD (Raw Mass Spectrometry)

Dataset population size: 606

OmicsDataType

The brain neurovascular epigenome and its association with dementia (GSE299072)0

OmicsDataType

Whole-blood RNA-seq data derived from C9orf72+ FTD spectrum cases and controls

Dataset population size: 114

OmicsDataType

EPAD LCS v.IMI

Dataset population size: 2,096

Health and disease

Brain vascular single-cell multi-omics elucidates disease risk associations0

OmicsDataType

PREVENT Dementia Research Programme

Dataset population size: 700

Health and disease

Locus Ceruleus Across Aging and Alzheimer's Pathology

Dataset population size: 126

OmicsDataType

CHARIOT PRO SUBSTUDY DATASET - CLINICAL

Dataset population size: 519

Health and disease, OmicsDataType

Emory White Matter Hyperintensity

Dataset population size: 195

OmicsDataType

Turkish Neurodegenerative Group-Dokuz Eylül University

Dataset population size: 380

Health and disease

AMYPAD PNHS (Raw) v202606

Dataset population size: 3,266

Health and disease

AMYPAD PNHS (Harmonised and Derived) v202606

Dataset population size: 3,266

Health and disease

EPAD LCS v.IMI (Imaging)

Dataset population size: 2,096

Health and disease, ImagingTypes

EPAD LCS v.IMI (Biosamples)

Dataset population size: 2,096

Health and disease

EPND Microbiome study

Dataset population size: 1,152

Health and disease, OmicsDataType

ALFA Study Dataset

Dataset population size: 419

Health and disease, OmicsDataType

HBDx-AD – MicroRNAs for the Diagnosis of Alzheimer’s Disease

Dataset population size: 1,659

OmicsDataType, Health and disease

BioFINDER Proteomics plasma and CSF Olink

Dataset population size: 2,000

Health and disease, OmicsDataType

Geriatric Cognitive Evaluation

Dataset population size: 1,731

Health and disease

Ancestry-Specific Structural Variation at 17q21.31 Reveals a Novel H1 Sub-Haplotype and Functional Effects on Tau Biology0

OmicsDataType

Predicting relevant microglia-associated cell-cell communication pathways in Alzheimer’s disease: a role for SPP10

OmicsDataType

Differentially expressed miRNAs in the temporal cortex of Alzheimer’s disease patients and their association to tau pathology.0

OmicsDataType

A cerebrospinal fluid microRNA analysis of progressive supranuclear palsy.0

OmicsDataType

Distinct tau neuropathology and cellular profiles of a APOE3 Christchurch homozygote protected against Autosomal Dominant Alzheimer’s dementia0

OmicsDataType

Distribution of big tau isoforms in the human central and peripheral nervous system0

OmicsDataType

Single-nucleus multi-omics identifies shared and distinct pathways in Pick’s and Alzheimer’s disease

Dataset population size: 16

OmicsDataType

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease - GSE76105

Dataset population size: 68

Health and disease

AD Synthetic Patient Data

Dataset population size: 5,000

Health and disease

BLSA Synthetic Data

Dataset population size: 2,210

Health and disease

CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks

Dataset population size: 1

Health and disease

Dementia Drivers IHME0

Health and disease

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s d

Dataset population size: 1

Health and disease

CRISPRi Screens in iPSC derived neurons0

Health and disease

DPUK Synthetic Dataset

Dataset population size: 150,618

Health and disease

NPH Integrative Analysis Datasets

Dataset population size: 1

Health and disease

Synthetic EPAD dataset

Dataset population size: 200

Health and disease

Digital Medicine Society Mixed Method Survey of Meaningful Aspects of Health in Alzheimer’s Disease and Related Dementias (ADRD)

Dataset population size: 1,007

Health and disease

Bulk whole genome sequencing of cells derived from dermis and postmortem dura mater from the same subject

Dataset population size: 1

Health and disease

Brain long read sequencing

Dataset population size: 17

Health and disease

Oxord Parkinson's Disease Centre (OPDC)-Discovery Cohort

Dataset population size: 1,300

Health and disease

MAUCO Cohort study

Dataset population size: 400

Health and disease, OmicsDataType

INSPIRE-T

Dataset population size: 1,164

Health and disease

BLSA DNA methylation - 450k

Dataset population size: 768

OmicsDataType

EPAD Scotland Baseline

Dataset population size: 101

Health and disease

EPAD LCS v500.0

Dataset population size: 500

Health and disease

EPAD LCS v500.1

Dataset population size: 500

Health and disease

EPAD LCS v1500.0

Dataset population size: 1,500

Health and disease

Analysis Scripts & Software(2)

Federated Data Sharing Appliance (FDSA)Alzheimer’s Disease Data Initiative

Eoghan Forde

Created - 19 October 2026

Alzheimer’s Disease Workbench (AD Workbench)Alzheimer’s Disease Data Initiative

Eoghan Forde

Created - 19 October 2026

Associated collections(1)

Alzheimer's Disease Data Initiative - Data Pilots

Alzheimer’s Disease Data Initiative

Datasets

Collections

Analysis Scripts & Software

Data Uses

Publications